Retatrutide: The Science Behind Your Weight Loss
A triple-action GLP-1/GIP/glucagon receptor agonist, studied in the Phase 3 TRIUMPH-1 trial with over 2,300 participants.
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Medicine That Works on Your Biology
Retatrutide activates three receptors — GLP-1, GIP, and glucagon — to change how your body handles hunger, energy, and weight.
GLP-1 Comparison
Retatrutide targets three receptors instead of one, delivering the greatest weight loss recorded in obesity trials.
| Medication | Receptors | Avg Weight Loss |
|---|---|---|
| SemaglutideOzempic® / Wegovy® | GLP-1 | ~15% |
| RetatrutideNext-gen triple agonist | GLP-1 + GIP + glucagon | ~30% |
*Retatrutide data from TRIUMPH-1 Phase 3 (Eli Lilly, 2026). Semaglutide data from STEP-1 (N Engl J Med, 2021). Maximum doses compared. These figures reflect the investigational retatrutide studied by Eli Lilly, not the compounded retatrutide RETA MD dispenses, and retatrutide is not yet FDA-approved. Individual results may vary.
What to Expect Month by Month
Weight comes off gradually and safely as your dose is titrated up under physician supervision.
Up to 1.0%
total body-weight reduction in clinical trials*
Getting Started
Your physician starts you at a low dose and you learn the weekly injection routine. Your body is adjusting, so this is when side effects are most likely. Mild nausea is common in this class of medication and usually eases with time.
Finding Your Dose
Your physician reviews how you are tolerating treatment and whether to adjust your dose. Nothing is automatic here. Changes are based on your response and your side effects, not on a fixed schedule.
Settling Into a Routine
By now you and your physician have a clearer picture of how you respond. Dose adjustments continue only if they are clinically appropriate, and you stay in contact between refills.
Ongoing Care
Treatment becomes part of your routine, with regular check-ins to review how it is working, how you are feeling, and whether anything needs to change. Results vary from person to person.
See if retatrutide is right for you.
Start with a few basics, and a licensed physician takes it from there. You pay nothing until they have reviewed you. No waiting rooms.
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